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Research Progress of Metformin in the Treatment of Oral Squamous Cell Carcinoma
Endocrinology. 2023 Sep 20:bqad139. doi: 10.1210/endocr/bqad139. Online ahead of print.ABSTRACTOral squamous cell carcinoma (OSCC) is one of the most common malignancies with high mortality, posing a great threat to both human physical and mental health. With the advancement of scientific research, a variety of cancer therapies have been used for OSCC treatment. However, the prognosis of OSCC shows no significant improvement. Metformin has been recognized as the first-line drug for the treatment of diabetes, and recent studies have shown that metformin has a remarkable suppressive effect on tumor progression. Metformin can...
Source: Endocrinology - September 22, 2023 Category: Endocrinology Authors: Jiayi Liu Jing Zhao Xue Qiao Source Type: research
STAT3-EphA7 axis contributes to the progression of esophageal squamous cell carcinoma
CONCLUSION: Our results showed that the transcriptional expression of EphA7 was increased by activated STAT3, and the STAT3 signaling may act through EphA7 to promote the development of ESCC.PMID:37738252 | DOI:10.1080/0284186X.2023.2259601
Source: Acta Oncologica - September 22, 2023 Category: Cancer & Oncology Authors: Li Wang Qiao-Feng Zhao Bing-Bing Yang Hui-Jie Liang Xian-E Zhang Xiao-Yan Zhang Wan-Jing Yang Zhi-Yu Guo Xin Xu Fang Tian Qing-Hua Wu Source Type: research
The combination of PAC-1 and entrectinib for the treatment of metastatic uveal melanoma
This study is an initial demonstration that the combination of PAC-1 and entrectinib may warrant further clinical investigation. Clinical trial registration: Clinical Trials.gov: NCT04589832.PMID:37738028 | DOI:10.1097/CMR.0000000000000927
Source: Cell Research - September 22, 2023 Category: Cytology Authors: Matthew W Boudreau Emily J Tonogai Claire P Schane Min X Xi James H Fischer Jayanthi Vijayakumar Yan Ji Theodore M Tarasow Timothy M Fan Paul J Hergenrother Arkadiusz Z Dudek Source Type: research
Extended duration of treatment using reduced-frequency dosing of anti-PD-1 therapy in patients with advanced melanoma and Merkel cell carcinoma
CONCLUSIONS: ICI administration at RFD can allow extension of treatment duration, while preserving efficacy and reducing logistical and financial burden. RFD approach deserves further exploration in prospective clinical trials.PMID:37733060 | DOI:10.1007/s00262-023-03539-8
Source: Cancer Control - September 21, 2023 Category: Cancer & Oncology Authors: Lisa May Ling Tachiki Daniel S Hippe Karly Williams Silva Evan Thomas Hall William McCamy Dane Fritzsche Andrea Perdue Julia Majovski Thomas Pulliam Daniel A Goldstein Joshua Veatch Joel Ho Paul T Nghiem John A Thompson Shailender Bhatia Source Type: research
Boiling histotripsy induces dendritic cell activation and acquisition of antigen in tumor draining lymph nodes
bioRxiv. 2023 Sep 6:2023.09.02.552844. doi: 10.1101/2023.09.02.552844. Preprint.ABSTRACTBoiling histotripsy (BH), a mechanical focused ultrasound ablation strategy, can elicit intriguing signatures of anti-tumor immunity. However, the influence of BH on dendritic cell function is unknown, compromising our ability to optimally combine BH with immunotherapies to control metastatic disease. Here, by applying BH to B16F10 melanoma expressing a ZsGreen antigen in a monotherapy protocol that elicits abscopal tumor control, we observed a marked increase in antigen acquisition by multiple phagocytic immune cells, including convent...
Source: Cancer Control - September 21, 2023 Category: Cancer & Oncology Authors: Eric A Thim Lydia E Petricca F átima Rivera-Escalera Alexander S Mathew Michael R Elliott Timothy N J Bullock Richard J Price Source Type: research
Indoloquinazoline alkaloids suppress angiogenesis and inhibit metastasis of melanoma cells
Bioorg Chem. 2023 Sep 18;141:106873. doi: 10.1016/j.bioorg.2023.106873. Online ahead of print.ABSTRACTMetastasis is the leading cause of cancer-related mortality, targeting angiogenesis emerges as a therapeutic strategy for the treatment of melanoma metastasis. Discovery of new antiangiogenic compounds with specific mechanism of action is still desired. In present study, a bioassay-guidance uncovers the EtOAc extract of a marine-derived fungus Aspergillus clavutus LZD32-24 with significant inhibitory activity against the angiogenesis in Tg (fli1a: EGFP) zebrafish model. Extensive chromatographic fractionation led to the is...
Source: Bioorganic Chemistry - September 21, 2023 Category: Chemistry Authors: Xingchen Guo Aili Fan Xinyi Qi Dong Liu Jian Huang Wenhan Lin Source Type: research
Topical Calcipotriol Plus Imiquimod Immunotherapy for Nonkeratinocyte Skin Cancers
In this study, we demonstrate that topical TSLP cytokine inducers-calcipotriol and retinoic acid-synergize with IMQ to activate CD4+ T-cell immunity against nonkeratinocyte cutaneous malignancies. Topical calcipotriol plus IMQ treatment reduced breast tumor growth compared with calcipotriol or IMQ alone (P < 0.0001). Calcipotriol plus IMQ-mediated tumor suppression was associated with significant infiltration of CD4+ effector T cells in the tumor microenvironment. Notably, topical calcipotriol plus IMQ immunotherapy enabled immune checkpoint blockade therapy to effectively control immunologically cold breast tumors, whi...
Source: Cancer Control - September 21, 2023 Category: Cancer & Oncology Authors: Marjan Azin Kenneth H Ngo Jennet Hojanazarova Shadmehr Demehri Source Type: research
Role of tissue markers associated with tumor microenvironment in the progression and immune suppression of oral squamous cell carcinoma
Med Oncol. 2023 Sep 20;40(10):303. doi: 10.1007/s12032-023-02169-5.ABSTRACTHead and neck cancers (HNC) continues to dominate major cancers contributing to mortality worldwide. Squamous cell carcinoma is the major type of HNC. Oral Squamous Cell Carcinoma grouped under HNC is a malignant tumor occurring in the oral cavity. The primary risk factors of OSCC are tobacco, alcohol consumption, etc. This review focuses on modulations, mechanisms, growth and differentiation of oral squamous cell carcinoma. Cancer cell surrounds itself with a group of elements forming a favorable environment known as tumor microenvironment (TME). I...
Source: Cancer Control - September 21, 2023 Category: Cancer & Oncology Authors: Suganya Ramalingam Sivaramakrishnan Shantha Susruthan Muralitharan Uma Sudhakar Harikrishnan Thamizhchelvan Venkatachalam Deepa Parvathi Source Type: research
Albendazole induces an anti-tumor effect and potentiates PD-L1 blockade immunotherapy
CONCLUSION: ABZ inhibits melanoma growth and metastasis. Moreover, ABZ synergized with PD-L1 blockade mediates tumor regression.PMID:37730912 | DOI:10.1007/s00432-023-05415-5
Source: Cancer Control - September 21, 2023 Category: Cancer & Oncology Authors: Weinan Zhang Zhiqiang He Fucheng Liang Jie Gong Liuchang Tan Juan Yang Siji Song Luoyingzi Xie Yuangang Lu Source Type: research
A Review on the Antimutagenic and Anticancer Effects of Cysteamine
In conclusion, regarding the high safety profile of cysteamine and the current literature data presented in this article, cysteamine might be considered as an interesting molecule for the prevention and the treatment of cancer. Further clinical studies should be performed to support these data in humans.PMID:37731680 | PMC:PMC10508993 | DOI:10.1155/2023/2419444
Source: Adv Data - September 21, 2023 Category: Epidemiology Authors: Chun-Man Lee Source Type: research
Durable complete response to early immunotherapy discontinuation in a kidney transplant recipient with advanced cutaneous squamous cell carcinoma: A case report and review of literature
CONCLUSION: Organ transplant recipients with complete response to immunotherapy for cutaneous squamous cell carcinoma may continue to respond despite early treatment cessation. This may reduce the risks of late immune-related adverse events and acute graft rejection.PMID:37734447 | DOI:10.1016/j.trim.2023.101932
Source: Transplant Immunology - September 21, 2023 Category: Transplant Surgery Authors: Ziyao Lu Mohammed Afzal Keisuke Shirai Source Type: research
Different mechanisms of CD200-CD200R induce diverse outcomes in cancer treatment
Math Biosci. 2023 Sep 19:109072. doi: 10.1016/j.mbs.2023.109072. Online ahead of print.ABSTRACTThe CD200 is a cell membrane protein expressed by tumor cells, and its receptor CD200 receptor (CD200R) is expressed by immune cells including macrophages and dendritic cells. The formation of CD200-CD200R inhibits the cellular functions of the targeted immune cells, so CD200 is one type of the immune checkpoint and blockade CD200-CD200R formation is a potential cancer treatment. However, the CD200 blockade has opposite treatment outcomes in different types of cancers. For instance, the CD200R deficient mice have a higher tumor l...
Source: Mathematical Biosciences - September 21, 2023 Category: Statistics Authors: Kang-Ling Liao Kenton D Watt Tom Protin Source Type: research
Long non-coding RNA as a potential diagnostic biomarker in head and neck squamous cell carcinoma: A systematic review and meta-analysis
ConclusionsLncRNAs could be used as diagnostic biomarkers for HNSCC, but further investigation is needed to validate clinical efficacy and elucidate mechanisms. High-throughput sequencing and bioinformatics should be used to ascertain expression profiles.
Source: PLoS One - September 21, 2023 Category: Biomedical Science Authors: Mahdi Masrour Source Type: research
